Opening balances are what each account held on the day you start using QuickBooks — enter them from a prior trial balance or reconciled statements so the books begin in agreement with reality.
This is the step that most often goes wrong. If the business has prior accounting, the cleanest source is a trial balance dated the day before your QuickBooks start date: it lists every account and its balance, and the debits equal the credits. Enter each balance as of that start date. For bank and credit-card accounts, use the ending balance from the last reconciled statement, not today's live balance, so the account can be reconciled forward cleanly.
The trap is Opening Balance Equity. QuickBooks parks the offsetting side of each opening balance in that account, and it is supposed to be cleared to retained earnings or owner's equity once every balance is in and the books tie out. Left sitting, it is a flag that setup was never finished. If you cannot produce a clean prior trial balance, you are really doing a migration or a catch-up, not a fresh setup — that changes the sequence.